American Chemical Society
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Synthesis and Studies of Mononucleoside Glucosyl Phosphotriester Derivatives

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journal contribution
posted on 1997-10-17, 00:00 authored by Nathalie Schlienger, Christian Périgaud, Gilles Gosselin, Jean-Louis Imbach
The synthesis and stability studies in several aqueous media of mononucleoside glucosyl phosphotriester derivatives of 3‘-azido-3‘-deoxythymidine are reported herein. Such neutral mononucleotides, which incorporate β-glucopyranosidyl moieties associated to a thioethyl linker as phosphate protecting groups were designed to act as “pronucleotides”, giving rise to the corresponding 5‘-mononucleotide through a glucosidase-mediated activation mechanism.