American Chemical Society
ol1003302_si_001.pdf (895.73 kB)

Synthesis and Structural Analysis of a New Class of Azaspiro[3.3]heptanes as Building Blocks for Medicinal Chemistry

Download (895.73 kB)
journal contribution
posted on 2010-05-07, 00:00 authored by Johannes A. Burkhard, Carine Guérot, Henner Knust, Mark Rogers-Evans, Erick M. Carreira
Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.