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Synthesis and Stability of Oligonucleotides Containing Acyclic Achiral Nucleoside Analogues with Two Base Moieties

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posted on 2004-01-08, 00:00 authored by Tongfei Wu, Matheus Froeyen, Guy Schepers, Kristof Mullens, Jef Rozenski, Roger Busson, Arthur Van Aerschot, Piet Herdewijn
Nucleotide building blocks with two base moieties were synthesized and incorporated into oligonucleotides. One of the two bases is involved in base pairing within the double helix, while the other base is sticking out of the minor groove. This system may be used for presenting sequence information at the outside of the helix.

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