Synthesis and Properties of a New Member of the Calixnaphthalene Family: A C2-Symmetrical endo-Calixnaphthalene
journal contributionposted on 29.08.2002, 00:00 by Sultan Chowdhury, Paris E. Georghiou
The synthesis of a new endo-calixnaphthalene is described. The reaction sequence involves the cyclocondensation of a key bisnaphthylmethane intermediate (8) with formaldehyde. This key intermediate (8) is formed using a modified Suzuki−Miyaura Pd-catalyzed cross-coupling reaction between bromomethylnaphthyl (6) and naphthylboronic acid (7), both of which can be derived from 2-hydroxynaphthoic acid.