np9007975_si_001.pdf (591.74 kB)
Download file

Synthesis and Characterization of an Epimer of Tacrolimus, an Immunosuppressive Drug

Download (591.74 kB)
journal contribution
posted on 23.04.2010, 00:00 authored by Dorthe M. Skytte, Karla Frydenvang, Liselotte Hansen, Peter G. Nielsen, Jerzy W. Jaroszewski
8-Epitacrolimus (2), a new l-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506, 1), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.