Synthesis and Biological Evaluation of
Manzamine Analogues

Winkler, Jeffrey D.; Londregan, Allyn T.; Ragains, Justin R.; Hamann, Mark T.

doi:10.1021/ol061320b.s001

Synthesis and Biological Evaluation of Manzamine Analogues

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posted on 2006-07-20, 00:00 authored by Jeffrey D. Winkler, Allyn T. Londregan, Justin R. Ragains, Mark T. Hamann

The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.

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series manzamine analogue Biological Evaluation Plasmodium falciparum evaluation pentacyclic ABCDE diamine core compound attenuated antimalarial activity Manzamine AnaloguesThe synthesis Synthesi

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Synthesis and Biological Evaluation of Manzamine Analogues

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