Synthesis and Biological Evaluation of
Manzamine Analogues

Winkler, Jeffrey D.; Londregan, Allyn T.; Ragains, Justin R.; Hamann, Mark T.

doi:10.1021/ol061320b.s001

Synthesis and Biological Evaluation of Manzamine Analogues

journal contribution

posted on 2006-07-20, 00:00 authored by Jeffrey D. Winkler, Allyn T. Londregan, Justin R. Ragains, Mark T. Hamann

The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against <i>Plasmodium falciparum</i> and demonstrated attenuated antimalarial activity relative to that of manzamine A.