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Synthesis and Biological Evaluation of Aminopolyamines

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journal contribution
posted on 05.05.2005, 00:00 by Raymond J. Bergeron, Guangfei Huang, James S. McManis, Hua Yao, John Nhut Nguyen
Exploitation of the polyamine backbone as a vector for intracellular transport of various pharmacophores has focused largely on fixing the cargo molecule to one of the nitrogens in the linear chain. This communication describes the assembly of a model aminopolyamine analogue, 6-amino-N,N12-diethylspermine, and its biological properties. This amino polyamine presents an additional site of attachment for cargo molecules, reduces cell growth, and achieves cellular concentrations that are higher than those of N1,N12-diethylspermine.