American Chemical Society
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Synthesis, Structure, and Reactivity of closo-2,3,4,5,6,7,8,9,10,11-Decahydroxy-1,12-bis(sulfonic acid)-1,12-dicarbadodecaborane(12)

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journal contribution
posted on 2001-12-01, 00:00 authored by Axel Herzog, Carolyn B. Knobler, M. Frederick Hawthorne
The reaction of closo-1,12-bis(lithio)-1,12-dicarbadodecaborane(12) (1,12-bis(lithio)-p-carborane) with SO2 formed closo-1,12-bis(lithiosulfinato)-p-carborane (10) in nearly quantitative yield. The latter was converted to closo-1,12-bis(sulfinic acid)-p-carborane (13) via H+-exchange. The corresponding 1,12-bis(sulfonic acid) derivative of p-carborane (12) was obtained in high yield by treating 10 with SO2Cl2 and subsequent AlCl3 mediated hydrolysis of the closo-1,12-bis(chlorosulfonyl)-p-carborane intermediate. The exhaustive oxidation of 12 in hot aqueous H2O2 (30%) afforded B-decahydroxy-1,12-bis(sulfonic acid)-p-carborane (15) in 40% yield. As a byproduct, closo-B-decahydroxy-1-sulfonic acid-p-carborane (14) was formed. Both 14 and 15 were also obtained from the hydroxylation of 10 and 13. Compound 14 was obtained directly in 88% yield by heating 1-sulfinic acid-p-carborane (17) in H2O2 (30%). Compound 17 was synthesized from diphenylmethylsilyl-protected p-carborane by using the method employed in the synthesis of 13. The X-ray structures of 15, its disodium salt, and its dipotassium salt are presented and discussed. Exhaustive methylation of 15 with methyl triflate furnishes closo-B-decamethoxy-1,12-bis(methyl sulfonate)-p-carborane (20). The characterization of closomer 20 also includes its crystal structure determination.