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Synergistic Multimodal Cancer Therapy Using Glucose Oxidase@CuS Nanocomposites

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journal contribution
posted on 26.08.2021, 19:07 by Parbeen Singh, Brian Youden, Yikun Yang, Yongli Chen, Andrew Carrier, Shufen Cui, Ken Oakes, Mark Servos, Runqing Jiang, Xu Zhang
Multimodal nanotherapeutic cancer treatments are widely studied but are often limited by their costly and complex syntheses that are not easily scaled up. Herein, a simple formulation of glucose-oxidase-coated CuS nanoparticles was demonstrated to be highly effective for melanoma treatment, acting through a synergistic combination of glucose starvation, photothermal therapy, and synergistic advanced chemodynamic therapy enabled by near-infrared irradiation coupled with Fenton-like reactions that were enhanced by endogenous chloride.

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