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Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides

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journal contribution
posted on 2004-02-11, 00:00 authored by Jianrong (Steve) Zhou, Gregory C. Fu
The capacity to employ unactivated alkyl electrophiles as coupling partners will markedly increase the already exceptional utility of metal-catalyzed cross-coupling processes. This communication describes the development of a method that achieves the first Suzuki reactions of unactivated secondary alkyl bromides and iodides. The ability to couple readily available, easy-to-handle boronic acids is an attractive feature of this catalyst system.

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