posted on 2018-12-03, 16:25authored byYoon Kyung Jang, Tobias Krückel, Magnus Rueping, Osama El-Sepelgy
The first example
of manganese-catalyzed C-alkylation
of the carboxylic acid derivatives is reported. The bench-stable homogeneous
manganese complex enables the transformation of the renewable alcohol
and carboxylic acid derivative feedstock to higher value esters and
amides. The reaction operates via hydrogen autotransfer and ideally
produces water as the only side product. Importantly, aliphatic-,
benzylic-, and heterocyclic-containing alcohols can be used as alkylating
reagents, eliminating the need for mutagenic alkyl halides.