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Surfaces with Dual Functionality through Specific Coimmobilization of Self-Assembled Polymeric Nanostructures
journal contribution
posted on 2018-10-08, 00:00 authored by Serena Rigo, Gesine Gunkel-Grabole, Wolfgang Meier, Cornelia G. PalivanCoimmobilization
of functional, nanosized assemblies broadens the
possibility to engineer dually functionalized active surfaces with
a nanostructured texture. Surfaces decorated with different nanoassemblies,
such as micelles, polymersomes, or nanoparticles are in high demand
for various applications ranging from catalysis, biosensing up to
antimicrobial surfaces. Here, we present a combination of bio-orthogonal
and catalyst-free strain-promoted azide–alkyne click (SPAAC)
and thiol–ene reactions to simultaneously coimmobilize various
nanoassemblies; we selected polymersome–polymersome and polymersome–micelle
assemblies. For the first time, the immobilization method using SPAAC
reaction was studied in detail to attach soft, polymeric assemblies
on a solid support. Together, the SPAAC and thiol–ene reactions
successfully coimmobilized two unique self-assembled structures on
the surfaces. Additionally, poly(dimethylsiloxane) (PDMS)-based polymersomes
were used as “ink” for direct immobilization from a
PDMS-based microstamp onto a surface creating locally defined patterns.
Combining immobilization reactions has the advantage to attach any
kind of nanoassembly pairs, resulting in surfaces with “desired”
interfacial properties. Different nanoassemblies that encapsulate
multiple active compounds coimmobilized on a surface will pave the
way for the development of multifunctional surfaces with controlled
properties and efficiency.
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self-assembled structuresimmobilization methodimmobilization reactionsantimicrobial surfacesnanostructured textureDifferent nanoassembliesSpecific Coimmobilizationnanoassembly pairscompounds coimmobilizedPDMS-based microstampDual Functionalityengineer dually functionalizedmultifunctional surfacespolymersomeSPAAC reactionnanosized assembliesSelf-Assembled Polymeric Nanostructures Coimmobilization
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