Surface-Modified Carbon Felts: Possible Supports for Combinatorial Chemistry
journal contributionposted on 02.11.2002, 00:00 by Estelle Coulon, Jean Pinson, Jean-Dominique Bourzat, Alain Commerçon, Jean-Pierre Pulicani
It is possible to prepare carbon-based analogues of the Merrifield resin by electrochemical reduction of diazonium salts or oxidation of aryl acetates on high specific surface area carbon felts. These modified felts can undergo further reactions: nucleophilic substitution, Suzuki reaction, and finally reductive electrochemical cleavage, taking advantage of the conductivity of the carbon felt. This provides a simple example of the possible use of electrochemistry in combinatorial synthesis.