Supramolecular Assemblies in Ionic Liquid Catalysis for Aza-Michael Reaction

Supramolecular assemblies formed by a relay of cooperative hydrogen bonds and charge−charge interactions have been identified/characterized by (+ve) ESI and MALDI-TOF-TOF MS and MS−MS studies during the aza-Michael reaction of amines with α,β-unsaturated carbonyl compounds in the presence of ionic liquids (ILs) digging out the role of catalysis by ILs, forming the basis of rational design/selection as organocatalysts, and offering a diagnostic model to predict/rationalize the selectivity of the aza-Michael reaction in a competitive environment.