ac8b00621_si_001.pdf (436.41 kB)
Suppression of Protonated Organic Solvents in NMR Spectroscopy Using a Perfect Echo Low-Pass Filtration Pulse Sequence
journal contribution
posted on 2018-03-19, 00:00 authored by Peter W. A. HoweProton
NMR spectra are usually acquired using deuterated solvents,
but in many cases it is necessary to obtain spectra on samples in
protonated solvents. In these cases, the intense resonances of the
protonated solvents need to be suppressed to maximize sensitivity
and spectral quality. A wide range of highly effective solvent suppression
methods have been developed, but additional measures are needed to
suppress the 13C satellites of the solvent. Because the
satellites represent 1.1% of the original solvent signal, they remain
problematic if unsuppressed. The recently proposed DISPEL pulse sequences
suppress 13C satellites extremely effectively, and this
Technical Note demonstrates that combining DISPEL and presaturation
results in exceptionally effective solvent suppression. An important
element in the effectiveness is volume selection, which is inherent
within the DISPEL sequence. Spectra acquired in protonated dimethlysulfoxide
and tetrahydrofuran show that optimum results are obtained by modifying
the phase cycle, cycling the pulse-field gradients, and using broadband 13C inversion pulses to reduce the effects of radiofrequency
offset and inhomogeneity.
History
Usage metrics
Categories
Keywords
protonated solvents needvolume selectionpresaturation resultsNMR SpectroscopyProtonated Organic Solventsprotonated solventstetrahydrofuran showpulse-field gradientsDISPEL pulse sequencessuppression methodsDISPEL sequencePerfect Echo Low-Pass Filtration Pulse Sequence Proton NMR spectrabroadband 13 C inversion pulses13 C satellitesphase cycleprotonated dimethlysulfoxide
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC