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Supported Synthesis of Oxoapratoxin A

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journal contribution
posted on 05.06.2009, 00:00 by Arnaud Gilles, Jean Martinez, Florine Cavelier
A new synthesis of an oxazoline analogue of apratoxin A has been performed using a solid support. The efficient synthesis of the polyketide part on gram scale and the serine vinylogue is described. The use of chlorotrityl resin allowed the construction of two linear precursors corresponding to two different cyclization sites. This study describes a facile synthesis of analogues for future SAR studies of this potent antitumor compound.