American Chemical Society
ja077054u_si_002.pdf (4.17 MB)

Sulfonylimidates as Nucleophiles in Catalytic Addition Reactions

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journal contribution
posted on 2008-02-13, 00:00 authored by Ryosuke Matsubara, Florian Berthiol, Shū Kobayashi
The first catalytic addition reactions of sulfonylimidates have been accomplished. In the presence of a catalytic amount of DBU (normally 5−10 mol %), sulfonylimidates reacted with several N-protected imines, methyl acrylate, and azodicarboxylate to afford the corresponding addition adducts, sulfonylimidates, in excellent yields. In the addition reactions to imines, high anti-selectivity was observed. A novel direct formation of β-amino acid derivatives from aldehyde and sulfonylimidate is also described.