posted on 2018-07-16, 00:00authored byXu-Man Chen, Yong Chen, Xiao-Fang Hou, Xuan Wu, Bo-Han Gu, Yu Liu
A kind of supramolecular
assemblies was constructed from two water-soluble and biocompatible
saccharides, sulfonato-β-cyclodextrin (SCD) and chitosan, and
characterized by dynamic light scattering (DLS), UV–vis, scanning
electron microscopy (SEM), and transmission electron microscopy (TEM).
The results showed that such nanoparticles presented good stability
and controlled loading/release property, which enabled them as good
drug carrier for berberine chloride (BE), a representative drug from
traditional Chinese herbs. That is, the nanoparticles can load BE
with high stability in a low-pH environment like that of the stomach
but released BE when moved to a high-pH environment like that of the
intestine.