American Chemical Society
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Sulfated Meroterpenoids from the Brazilian Sponge Callyspongia sp. Are Inhibitors of the Antileishmaniasis Target Adenosine Phosphoribosyl Transferase

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journal contribution
posted on 2006-11-10, 00:00 authored by Christopher A. Gray, Simone P. de Lira, Marcio Silva, Eli F. Pimenta, Otavio H. Thiemann, Glaucius Oliva, Eduardo Hajdu, Raymond J. Andersen, Roberto G. S. Berlinck
Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 of 1.05 μM. The structures of 1, 2, and 3 were elucidated by analysis of one- and two-dimensional NMR data. Ilhabelanol (1) and ilhabrene (2) both have unprecedented meroterpenoid carbon skeletons.