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Download fileSubpicomolar Iron Sensing Platform Based on Functional Lipid Monolayer Microarrays
journal contribution
posted on 14.03.2016, 00:00 authored by Ahmad Kenaan, Tuyen D. Nguyen, Hervé Dallaporta, Jean-Manuel Raimundo, Anne M. CharrierWe report herein
the fabrication of novel microarrays based on
air-stable functional lipid monolayers over silicon using a combination
of e-beam lithography and lift-off. We demonstrate these microarrays
can be use as ultrasensitive platform for Kelvin probe force microscopy
in sensing experiments. Specificity of the detection is given by the
functional group grafted at the lipid headgroup. The arrays developed
for the detection of ferric ions, Fe3+, using a γ-pyrone
derivative chelator, demonstrate subpicomolar limit of detection with
high specificity. In addition, the technique takes advantage of the
structure of the array with the silicon areas playing the role of
reference for the measurement, and we determine critical pattern dimensions
below which the probe size/shape impacts the measured results.
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