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Studies toward the Synthesis of Spirolide C: Exploration into the Formation of the 23-Membered All-Carbon Macrocyclic Framework

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journal contribution
posted on 22.02.2016, 07:04 by Craig E. Stivala, Zhenhua Gu, Lindsay L. Smith, Armen Zakarian
The synthesis of two complex subunits en route to spirolide C is described. A key alkyllithium addition to an aldehyde joins the fragments, which are advanced in order to investigate a ring-closing metathesis to form the 23-membered all-carbon macrocyclic framework.