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Studies on the Synthesis of Tedanolide:  Synthesis of the C(5)−C(21) Segment via a Highly Stereoselective Fragment Assembly Aldol Reaction of a Chiral β,γ-Unsaturated Methyl Ketone

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posted on 24.05.1999, 00:00 authored by William R. Roush, Gregory C. Lane
A highly diastereoselective synthesis of 3, corresponding to the C(5)−C(21) segment of tedanolide, has been accomplished by a route utilizing the aldol reaction of aldehyde 4 and the β,γ-unsaturated methyl ketone 5.