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Studies on the Synthesis of Tedanolide. 2. Stereoselective Synthesis of a Protected C(1)−C(12) Fragment

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journal contribution
posted on 02.12.2002, 00:00 by William R. Roush, Jason S. Newcom
Highly diastereoselective syntheses of diketo esters 6a and 6b are described. These intermediates undergo efficient aldol reactions with protected C(13)−C(21) aldehydes 3 and 23, thereby providing advanced C(1)−C(21) tedanolide seco ester precursors 9a and 9b.

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