ol0600786_si_001.pdf (5.22 MB)

Studies in Macrolide Antibiotic Synthesis:  The Role of Tethered Alkoxides in Titanium Alkoxide-Mediated Regioselective Reductive Coupling Reactions

Download (5.22 MB)
journal contribution
posted on 16.03.2006, 00:00 by Adilah B. Bahadoor, Glenn C. Micalizio
A convergent route to a C1−C15 fragment precursor for erythromycin-based macrolide antibiotics is presented. These studies define a role for tethered alkoxides in the control of site-selective carbon−carbon bond formation in titanium alkoxide-mediated coupling reactions of internal alkynes and chiral aldehydes.