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Studies Toward the Total Synthesis of Angelmicin B (Hibarimicin B):  Synthesis of a Model CD−D‘ Arylnaphthoquinone

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journal contribution
posted on 14.10.2004, 00:00 by Sridhar Narayan, William R. Roush
A synthesis of arylnaphthoquinone 22 corresponding to the CD−D‘ unit of angelmicin B via the Suzuki coupling of the D‘ arylboronic acid 15 with the CD bromonaphthoquinone 21 is described. The mild conditions for the Suzuki cross-coupling leading to 22 may prove to be useful for the eventual late-stage coupling of the two highly functionalized halves of angelmicin B.