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Download fileStudies Targeting Ryanodol Result in an Annulation Reaction for the Synthesis of a Variety of Fused Carbocycles
journal contribution
posted on 12.07.2019, 12:34 authored by Rajdip Karmakar, Arnold L. Rheingold, Glenn C. MicalizioAn annulation reaction
is described to access a range of polycyclic
and highly oxygenated carbocycles. First developed in an approach
to the synthesis of ryanodol, metallacycle-mediated annulative diketone–alkyne
coupling defines a framework for realization of new retrosynthetic
relationships for complex molecule synthesis. In addition to demonstrating
this reaction in the context of forging distinct carbocyclic systems,
including those featuring a seven-membered ring, the choice of quenching
reagent leads to unique reaction outcomes.