Structure and Semisynthesis of Platensimide A, Produced by Streptomyces platensis
journal contributionposted on 01.05.2008, 00:00 by Kithsiri B. Herath, Chaowei Zhang, Hiranthi Jayasuriya, John G. Ondeyka, Deborah L. Zink, Bruce Burgess, Jun Wang, Sheo B. Singh
Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described.