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Structure and Absolute Configuration of Helosides A and B, New Saponins from Chamaelirium luteum

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journal contribution
posted on 22.07.2011, 00:00 by Victoria L. Challinor, Julia M. U. Stuthe, Paul V. Bernhardt, Reginald P. Lehmann, William Kitching, James J. De Voss
Investigation of Chamaelirium luteum roots led to the isolation of two new steroidal saponins, helosides A (1) and B (2), that contain a previously unreported aglycone, helogenin (3). Their structures and absolute configuration were elucidated through MS-MS, NMR, chemical degradation, and X-ray crystallography.