posted on 2013-04-26, 00:00authored byChang-Lun Shao, Ru-Fang Xu, Mei-Yan Wei, Zhi-Gang She, Chang-Yun Wang
Fumiquinazoline L (1), an alkaloid with a heptacyclic skeleton formed via a bridging
hemiaminal linkage, was isolated from a gorgonian-derived Scopulariopsis sp. fungus. The structure and absolute configuration
of the new compound were identified by comprehensive spectroscopic
data and X-ray diffraction analysis. During acid hydrolysis of 1, the isomerization of the valine residue was observed and
also studied in different conditions. Fumiquinazoline L (1) showed no cytotoxic or antibacterial activities.