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Striatoids A–F, Cyathane Diterpenoids with Neurotrophic Activity from Cultures of the Fungus Cyathus striatus

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posted on 24.04.2015, 00:00 authored by Rui Bai, Cheng-Chen Zhang, Xia Yin, Jing Wei, Jin-Ming Gao
Six new highly oxygenated polycyclic cyathane-xylosides, named striatoids A–F (16), were isolated from the cultures of the basidiomycete Cyathus striatus. Their structures were established by comprehensive spectroscopic analysis including 2D NMR (HMBC, HSQC, ROESY, 1H–1H–COSY) and HRESIMS experiments. Compounds 2 and 3 possess an unusual 15,4′-ether ring system. The isolated compounds dose-dependently enhanced nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma (PC-12) cells.