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Strain-Promoted Cross-Linking of PEG-Based Hydrogels via Copper-Free Cycloaddition

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journal contribution
posted on 20.02.2016, 14:08 by Jukuan Zheng, Laura A. Smith Callahan, Jinkun Hao, Kai Guo, Chrys Wesdemiotis, R. A. Weiss, Matthew L. Becker
The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly­(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide–alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms.