Stimuli Response of Cystamine-Core Dendrimer Revealed by Diffusion and NOE NMR Studies
journal contributionposted on 14.04.2011, 00:00 by Xueyan Feng, Yiyun Cheng, Qinglin Wu, Jiahai Zhang, Tongwen Xu
Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and dl-Dithiothreitol are described. A competitive redox cleavage and supramolecular aggregate formation model is proposed based on PFG NMR and 1H NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.