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Stimulation of Wound Healing by Electroactive, Antibacterial, and Antioxidant Polyurethane/Siloxane Dressing Membranes: In Vitro and in Vivo Evaluations
journal contribution
posted on 2015-11-04, 00:00 authored by Reza Gharibi, Hamid Yeganeh, Alireza Rezapour-Lactoee, Zuhair M. HassanA series
of novel polyurethane/siloxane-based wound dressing membranes
was prepared through sol–gel reaction of methoxysilane end-functionalized
urethane prepolymers composed of castor oil and ricinoleic methyl
ester as well as methoxysilane functional aniline tetramer (AT) moieties.
The samples were fully characterized and their physicochemical, mechanical,
electrical, and biological properties were assayed. The biological
activity of these dressings against fibroblast cells and couple of
microbes was also studied. It was revealed that samples that displayed
electroactivity by introduction of AT moieties showed a broad range
of antimicrobial activity toward different microorganisms, promising
antioxidant (radical scavenging) efficiency and significant activity
for stimulation of fibroblast cell growth and proliferation. Meanwhile,
these samples showed appropriate tensile strength and ability for
maintaining a moist environment over a wound by controlled equilibrium
water absorption and water vapor transmission rate. The selected electroactive
dressing was subjected to an in vivo assay using a rat animal model
and the wound healing process was monitored and compared with analogous
dressing without AT moieties. The recorded results showed that the
electroactive dressings induced an increase in the rate of wound contraction,
promoted collagen deposition, and encouraged vascularization in the
wounded area. On the basis of the results of in vitro and in vivo
assays, the positive influence of designed dressings for accelerated
healing of a wound model was confirmed.
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wound modelaniline tetramervivo assayswound healing processwound contractionrat animal modelantimicrobial activityelectroactive dressingvivo assaycastor oilfibroblast cell growthmoietiefibroblast cellssamplericinoleic methyl esterVivo EvaluationsA seriesWound Healingcollagen depositionelectroactive dressingswater vapor transmission rateequilibrium water absorption
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