posted on 2021-08-31, 14:36authored byQuentin
D. Tercenio, Erik J. Alexanian
The stereospecific cross-coupling
of easily accessed electrophiles
holds significant promise in the construction of C–C bonds.
Herein, we report a nickel-catalyzed reductive coupling of allyl alcohols
with chiral, nonracemic alkyl tosylates. This cross-coupling delivers
valuable allylation products with high levels of stereospecificity
across a range of substrates. The catalytic system consists of a simple
nickel salt in conjunction with a commercially available reductant
and importantly represents a rare example of a cross-coupling involving
the C–O bonds of two electrophiles.