Stereospecific Coupling of Boronic Esters with N‑Heteroaromatic Compounds
journal contributionposted on 17.12.2015, 09:26 by Josep Llaveria, Daniele Leonori, Varinder K. Aggarwal
A protocol for the stereospecific coupling of chiral secondary and tertiary boronic esters with lithiated N-heteroaromatics is described. The process involves initial boronate complex formation followed by addition of Troc-Cl, which activates the nitrogen and induces 1,2-migration. Oxidative workup furnishes the coupled product with >98% es.