American Chemical Society
ol4013537_si_001.pdf (4.19 MB)

Stereoselective and Regioselective Intramolecular Friedel–Crafts Reaction of Aziridinium Ions for Synthesis of 4‑Substituted Tetrahydroisoquinolines

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journal contribution
posted on 2013-12-06, 00:00 authored by Hyun-Soon Chong, Yunwei Chen
Optically active 4-substituted tetrahydroisoquinolines were synthesized via intramolecular Friedel–Crafts (FC) reactions of aziridinium ions in a highly regio- and stereoselective manner. Control experiments suggest the formation and ring-opening of aziridinium ions as the key intermediates in the Lewis acid catalyzed FC reactions.