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Stereoselective Synthesis of the Rocaglamide Skeleton via a Silyl Vinylketene Formation/[4 + 1] Annulation Sequence

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journal contribution
posted on 02.10.2008, 00:00 by Matthew W. Giese, William H. Moser
The tricyclic core of the cyclopentabenzofurans has been prepared in an efficient and stereoselective manner utilizing an intramolecular silyl vinylketene formation/[4 + 1] annulation sequence. This novel approach affords the ABC ring system where the adjacent phenyl and aryl substituents of the C ring have the required cis relationship.