American Chemical Society
jo5029419_si_001.pdf (6.1 MB)

Stereoselective Synthesis of the Diazonamide A Macrocyclic Core

Download (6.1 MB)
journal contribution
posted on 2015-03-20, 00:00 authored by Ilga Mutule, Beomjun Joo, Zane Medne, Toms Kalnins, Edwin Vedejs, Edgars Suna
Stereoselective synthesis of the right-hand heteroaromatic macrocycle of diazonamide A features C16–C18 bond formation in the Suzuki–Miyaura cross-coupling and atropodiastereoselective Dieckmann-type macrocyclization as key steps. The Suzuki–Miyaura cross-coupling gave the best yields when it was catalyzed by a palladium–dioxygen complex.