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Stereoselective Synthesis of a Model C(18)–C(35) Spiroketal Fragment of Integramycin

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journal contribution
posted on 20.05.2011, 00:00 by Huikai Sun, Jason R. Abbott, William R. Roush
A highly stereoselective synthesis of a model C(18)–C(35) spiroketal unit (7) of integramycin has been accomplished via an enantioselective stannyl-crotylboration reaction and an N-iodosuccinimide-mediated spiroketalization of 19a.