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Stereoselective Synthesis of Pyrrolidines from N-Allyl Oxazolidines via Hydrozirconation−Cyclization

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journal contribution
posted on 27.10.2005, 00:00 by Jean-Luc Vasse, Antoine Joosten, Clément Denhez, Jan Szymoniak
A new diastereoselective synthesis of pyrrolidines from readily available chiral N-allyl oxazolidines is presented. The construction of the pyrrolidine ring is achieved via a tandem hydrozirconation−stereoselective Lewis acid mediated cyclization sequence.