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Stereoselective Synthesis of Methyl Monate C

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journal contribution
posted on 21.12.2006, 00:00 by Livia van Innis, Jean Marc Plancher, István E. Markó
The stereoselective synthesis of methyl monate C 2 is described using as a key step an ene-intramolecular modified Sakurai cyclization (IMSC) reaction to prepare tetrahydropyran 5. An asymmetric allylic alkylation, followed by a cross-metathesis, enables the insertion of the right-hand side chain.