ol0060578_si_001.pdf (929.67 kB)
Download file

Stereoselective Synthesis of (−)-Acanthoic Acid

Download (929.67 kB)
journal contribution
posted on 17.06.2000, 00:00 by Taotao Ling, Bryan A. Kramer, Michael A. Palladino, Emmanuel A. Theodorakis
The first stereoselective synthesis of (−)-acanthoic acid (1) has been designed and accomplished. Our synthetic plan departs from (−) Wieland−Miesher ketone (7) and calls upon a Diels−Alder cycloaddition reaction for the construction of the C ring of 1. The described synthesis confirms the proposed stereochemistry of 1 and represents an efficient entry into an unexplored class of biologically active diterpenes.