ol801852j_si_002.pdf (1.35 MB)

Stereoselective Syntheses of the C(1)−C(9) Fragment of Amphidinolide C

Download (1.35 MB)
journal contribution
posted on 02.10.2008, 00:00 by Robert H. Bates, J. Brad Shotwell, William R. Roush
Stereoselective syntheses of the C(1)−C(9) fragments 18 and 28 of amphidinolide C have been developed. The first-generation sequence involves a diastereoselective chelate-controlled [3 + 2]-annulation reaction of 6 and 7, while the second-generation synthesis involves an intramolecular hetero-Michael cyclization of 8.