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Stereoselective Rhodium-Catalyzed Amination of Alkenes

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journal contribution
posted on 21.10.2011, 00:00 by Hélène Lebel, Cédric Spitz, Olivier Leogane, Carl Trudel, Michaël Parmentier
The first stereoselective rhodium-catalyzed intermolecular aziridination and C–H amination of alkenes to produce chiral carbamate-protected aziridines and allylic amines is described. Good yields and diastereoselectivities were achieved using a readily available chiral N-tosyloxycarbamate and stoichiometric amount of the alkene substrate. Furthermore the protecting group is easy to cleave under mild reaction conditions.