Stereoselective Rhodium-Catalyzed Amination of Alkenes
journal contributionposted on 21.10.2011, 00:00 by Hélène Lebel, Cédric Spitz, Olivier Leogane, Carl Trudel, Michaël Parmentier
The first stereoselective rhodium-catalyzed intermolecular aziridination and C–H amination of alkenes to produce chiral carbamate-protected aziridines and allylic amines is described. Good yields and diastereoselectivities were achieved using a readily available chiral N-tosyloxycarbamate and stoichiometric amount of the alkene substrate. Furthermore the protecting group is easy to cleave under mild reaction conditions.