ol7b00512_si_001.pdf (4.38 MB)
Stereoselective Palladium-Catalyzed Decarboxylative γ‑Arylation of Acyclic β,γ-Unsaturated Carboxylic Acids
journal contribution
posted on 2017-03-23, 15:04 authored by Ina Scheipers, Eva Koch, Armido StuderPalladium-catalyzed
γ-arylation of acyclic β,γ-unsaturated
carboxylic acids with various aryl iodides is reported. The cascade
comprises a decarboxylative γ-palladation of β,γ-unsaturated
α,α′-disubstituted carboxylic acids and subsequent
C(sp2)–C(sp3) bond formation to provide
diaryl vinyl methanes in moderate to good yields and high E/Z-selectivities. Reaction with an enantiomerically
pure acid revealed that the process occurs with high stereospecificity.