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Stereoselective Construction of the Highly Congested Tricyclic Core Structure in Leucosceptroid H

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journal contribution
posted on 03.06.2020, 22:29 by Peng Sun, Chi Zhang, Tianjiao Qiao, Junli Ao, Shuming Wu, Guangxin Liang
Leucosceptroids are sesterterpenoids with potent antifeedant and antifungal activities. An efficient stereoselective construction of the highly congested [5,6,5] tricyclic framework of leucosceptroid H is presented. This framework bearing eight contiguous stereogenic centers, including three tetrasubstituted ones, could serve as a common intermediate for the collective total synthesis of the leucosceptroid family of natural products.