ol049074w_si_004.pdf (7.07 MB)
Download fileStereocontrolled Total Synthesis of Potent Immunosuppressant FR901483
journal contribution
posted on 2004-08-05, 00:00 authored by Toshiyuki Kan, Teppei Fujimoto, Shigeru Ieda, Yusuke Asoh, Haruka Kitaoka, Tohru FukuyamaA total synthesis of the potent immunosuppressant FR901483 (1) has been accomplished. The key feature of our convergent synthesis is the
stereoselective incorporation of the p-methoxybenzyl and methylamino groups within the core moiety 10. Tricycle 10 was itself constructed
by an intramolecular aldol reaction of the symmetrical keto-aldehyde 7.