American Chemical Society
ol049074w_si_004.pdf (7.07 MB)

Stereocontrolled Total Synthesis of Potent Immunosuppressant FR901483

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journal contribution
posted on 2004-08-05, 00:00 authored by Toshiyuki Kan, Teppei Fujimoto, Shigeru Ieda, Yusuke Asoh, Haruka Kitaoka, Tohru Fukuyama
A total synthesis of the potent immunosuppressant FR901483 (1) has been accomplished. The key feature of our convergent synthesis is the stereoselective incorporation of the p-methoxybenzyl and methylamino groups within the core moiety 10. Tricycle 10 was itself constructed by an intramolecular aldol reaction of the symmetrical keto-aldehyde 7.