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Stereocontrolled Synthesis of Dafachronic Acid A, the Ligand for the DAF-12 Nuclear Receptor of Caenorhabditis elegans

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journal contribution
posted on 15.08.2007, 00:00 by Simon Giroux, E. J. Corey
An efficient synthetic route to the DAF-12 nuclear receptor ligand of C. elegans, dafachronic acid, is described that starts with the abundant plant sterol β-stigmasterol and proceeds in 37% overall yield. The synthesis establishes the structure of this rare nematode hormone.