Spongian Diterpenoids from the Sponge Spongia (Heterofibria) sp.

Ponomarenko, Ludmila P.; Kalinovsky, Anatoly I.; Afiyatullov, Shamil Sh.; Pushilin, Michail A.; Gerasimenko, Andrey V.; Krasokhin, Vladimir B.; Stonik, Valentin A.

doi:10.1021/np070068t.s001

np070068t_si_001.pdf (99.58 kB)

Spongian Diterpenoids from the Sponge Spongia (Heterofibria) sp.

journal contribution

posted on 2020-04-03, 13:30 authored by Ludmila P. Ponomarenko, Anatoly I. Kalinovsky, Shamil Sh. Afiyatullov, Michail A. Pushilin, Andrey V. Gerasimenko, Vladimir B. Krasokhin, Valentin A. Stonik

Five new (1, 2, 4−6) and one known (3) diterpenoid were isolated from the keratose sponge Spongia (Heterofibria) sp. Structures of these compounds and their absolute configurations were proposed on the basis of X-ray analysis of 1, its CD spectrum, and NMR and MS spectroscopic studies of 1−6. One of the new diterpenoids was shown to be 2(R),3(S),4(S)-3,18-methylene-2-acetoxyspongia-13(16),14-diene (6), possessing a novel carbon skeleton system.