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Spirohexenolide A Targets Human Macrophage Migration Inhibitory Factor (hMIF)

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journal contribution
posted on 24.05.2013, 00:00 by Wei-Lun Yu, Brian D. Jones, MinJin Kang, Justin C. Hammons, James J. La Clair, Michael D. Burkart
Spirohexenolides A and B comprise a unique family of spirotetronate natural products. We report on the identification of their binding to and modulation of human macrophage migration inhibitor factor (hMIF). Using an immunoaffinity–fluorescent labeling method, the properties of this interaction are detailed and evidence is provided that hMIF plays a key role in the cytostatic activity of the spirohexenolides.